Effect of Compound Danshen Dripping Pills on Cytochrome CYP1A2 Activity
- VernacularTitle:复方丹参滴丸对人肝脏药物代谢酶CYP1A2活性的影响
- Author:
Hui WU
- Publication Type:Journal Article
- Keywords:
Compound danshen dripping pills;
Cytochrome CYP1A2;
Caffeine metabolites;
RP-HPLC
- From:
China Pharmacy
2005;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of Compound danshen dripping pills on cytochrome CYP1A2 activity for reference of clinical rational drug use. METHODS: The contents of four major metabolites of Caffeine, i.e. 5-acetylamino-6-formylamino-3-methyluracil(AFMU),1-methylxanthine(1X), 1-methyluric acid(1U) and 1, 7-dimethyluricacid (17U) in the urine before and after oral administration of Compound danshen dripping pills were determined by RP-HPLC. The activity of cytochrome CYP1A2 was derived from the ratio of (AFMU+1X+1U)/17U. RESULTS: The average activity of CYP1A2 was 4.20?1.54 before medication, which stood at 4.26?1.95 at 14 days and 4.35?1.26 at 28 days after medication, up 1.42% and 3.57%, respectively, yet there was no significant difference after medication as compared with before medication. CONCLUSION: No significant difference was noted on CYP1A2 activity after oral medication of Compound danshen dripping pills, nor does it modify the efficacy of the concurrent drugs that metabolized by CYP1A2.
