Expression of IFN-? and IL-12 in patients with allergic rhinitis
- VernacularTitle:白细胞介素-12和干扰素-?表达与变应性鼻炎的相关性
- Author:
Jun YAO
;
Hui ZHOU
;
Mei XU
;
Yuefei ZHANG
- Publication Type:Journal Article
- Keywords:
Rhinitis, Allergic, Perennial;
Interleukin-12;
Interferon Type Ⅱ;
In Situ Hybridization;
Enzyme-Linked Immunosorbent Assay
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the relationship between allergic rhinitis and IFN-?, IL-12. METHODS The expression of IL-12 was detected by in situ hybridization and enzyme-linked immunosorbent assay in 37 patients with allergic rhinitis and 12 control samples. IFN-? was detected by ELISA. RESULTS The positive ratios of IL-12 in PBMC were 0.13?0.03 and 0.77?0.15 in allergic rhinitis group and control group respectively. The concentrations of IL-12 were (13.7?2.4 ) pg/L and (52.9?8.4 ) pg/L in allergic rhinitis group and control group respectively. The concentrations of IFN-? were (11.2?2.1 ) pg/L and (51.8 ?6.4) pg/L in allergic rhinitis group and control group respectively. CONCLUSION The down-regulation of IL-12 and IFN-? was related to allergic rhinitis, and hyper-function of Th2 cells may play an important role in the pathogenesis of allergic rhinitis.
