Influence of Shenfu injection(参附注射液)on tumor necrosis factor-?, interleukin-2 and lung function in patients with chronic obstructive pulmonary disease at acute exacerbation stage
- VernacularTitle:参附注射液对慢性阻塞性肺疾病急性加重期患者炎症细胞因子和肺功能的影响
- Author:
Wensheng LIAO
;
Weiqing LI
;
Shiwei CHEN
;
Qingshun HU
- Publication Type:Journal Article
- Keywords:
Shenfu injection;
chronic obstructive pulmonary disease;
tumor necrosis factor-?;
interleukin-2;
lung function
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical therapeutic effect of Shenfu injection (参附注射液) on patients with chronic obstructive pulmonary disease at acute exacerbation stage (AECOPD) and approach its therapeutic mechanism. Methods Fifty-eight patients with AECOPD were divided into a Shenfu group (30 cases) and a control group(28 cases); the Shenfu group received 50 ml Shenfu injection and 5% glucose 250 ml intravenous drip once a day at the base of conventional therapy,while the control group received conventional therapy only. The therapeutic course of both groups was 14 days. The clinical therapeutic effects of both groups were observed, the serum levels of tumor necrosis factor-? (TNF-?), interleukin-2 (IL-2) were measured by enzyme-labeled immunosorbent assay (ELISA), and the lung function of both groups was measured before and after the treatment. Results The total effective rates was 93.3% (28/30) and 85.7% (24/28) in the treatment group and the control group, respectively. In the comparison before and after treatment, the levels of TNF-? in both groups were decreased obviously (both P0.05). Conclusion Shenfu injection has a definite clinical curative effect in the treatment of AECOPD, it may decrease obviously the serum level of TNF-?, increase the level of IL-2 and improve the lung function in the patients with AECOPD.
