Detection and Drug Resistance of AmpC and Extended-spectrum ?-lactamase in Escherichia Coli from Urinary Infections
- VernacularTitle:尿路感染大肠埃希菌产AmpC酶和超广谱?-内酰胺酶的检测及耐药性分析
- Author:
Yanyan GUO
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Escherichia coli;
AmpC;
Extended-spectrum ?-lactamases;
Drug resistance
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect and analyze the drug resistance of the AmpC and the extended-spectrum ?-lactamases(ESBLs)in Escherichia coli(E coli)from urinary infections.METHODS:ESBLs was detected by Phenotypic Confirmatory Test and AmpC was detected by improved three dimensional test.RESULTS:The isolating rates of ESBLs(45 strains),AmpC(8 strains)and AmpC+ESBLs in E.coli(5 strains)were 34.6%,6.2% and 3.8%,respectively.The drug resistance rates of ESBLs and AmpC-producing E.coli was higher than those of the strains without producing ESBLs or AmpC.CONCLUSION:Production of AmpC and ESBLs in ?-lactam antibiotics was the main resistance mechanism against E.coli.Carbopenems should be regarded as the first choice in clinical empirical medication for enzyme-producing strains.
