Anticoagulation of Warfarin Therapy in Patients After Mechanical Valve Implantation
- VernacularTitle:心脏机械瓣膜置换术后华法林抗凝观察
- Author:
Fengbo WU
;
Ting XU
;
Zelian CHEN
;
Yao TANG
- Publication Type:Journal Article
- Keywords:
Warfarin;
Anticoagulation;
Mechanical heart valve;
International normalized ratio
- From:
China Pharmacy
2005;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the influencing factors of anticoagulation with warfarin in patients who had undergone artificial mechanical heart valve replacement and the relation between dosage regimens and international normalized ratio(INR).METHODS:123 patients who had undergone artificial valve replacement patients were followed-up.The patients were treated with warfarin therapy for anticoagulation after surgery,and given a regular follow-up.Patients' age,gender,and INR value etc were recorded and the adverse events including bleeding,embolism and death were observed.RESULTS:No death case was reported;femoral vein thrombosis occurred in 1 case;gingival bleeding occurred in 11 cases and urinary tract bleeding was noted in 3 case.The incidence of anticoagulation-associated ADR was close to that reported in overseas literature.CONCLUSION:According to INR,individual dose of warfarin should be administered on day 5 after artificial valve replacement.Maintaning INR at 1.5～2.0 can achieve certain anticoagulation efficacy and is relatively safe.
