Changes in Electrophysiology and Ultramicrostructure after Noise Exposure in Cochlea of Guinea Pigs
- VernacularTitle:噪声暴露后豚鼠耳蜗电生理和超微结构的改变
- Author:
Xiaowei LIU
;
Jingwu SUN
- Publication Type:Journal Article
- Keywords:
Noise;
ABR;
Guinea pig;
Hair cell;
Scanning electron microscope
- From:
Journal of Audiology and Speech Pathology
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in electrophysiology and ultramicrostructureafter noise exposure in cochlea of guinea pigs. Methods Thirty animals were divided into 4 groups:group 1 was normal animals,while group 2,3 and 4 were animals of 0.5 hours,7 days and 3 weeks after exposed to noise of 120 dB SPL for 2 hours, respectively.The ABR and 40 Hz-AERP were measured before and after exposure. The hair cells were observed by scanning electron microscope.Results The amplitudes of ABR and 40 Hz-AERP disappeared right after noise exposure, however,they returned to normal 7 days and 3 weeks later . The scanning electron microscopy showed the stereocilia of the hair cells were disarranged and some disappeared at the second and fourth circle of the cochlea . The changes of the pathology at the fourth circle were more serious than that of the second circle. Conclusion The stereocilia of the hair cells had recovered after noise exposure.
