Changes in TCR V? subfamily nave T cells in peripheral blood of patients with multiple myeloma
- VernacularTitle:多发性骨髓瘤患者外周血中TCR V?亚家族nave T细胞水平变化
- Author:
Qingsong YIN
;
Yangqiu LI
;
Lijian YANG
;
Shaohua CHEN
;
Yubing ZHOU
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Nave T cells;
Thymus gland
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To detect the existence of signal joint T-cell receptor excision DNA circles(sjTRECs)of 23 TCR V? subfamilies in mononuclear cells of patients with multiple myeloma(MM),and to evaluate the recent thymic emigrants of corresponding V? subfamily nave T cells in MM patients.METHODS:23 TCR V? subfamily sjTRECs were amplified in genomic DNA from 5?104 PBMCs of 12 cases in MM patients by using semi-nest PCR.10 normal individuals served as controls.RESULTS:The number of detectable V? subfamily sjTRECs was 5.00?2.45 from MM patients,as compared with 9.60?5.48 from normal individuals,the difference was significant(P
