Study on the Factors that Effected Loaded Dosage of Ursolic Acid Complex with Orthogonal Design and Gray Relation Analysis
- VernacularTitle:正交试验设计与灰色关联度分析用于熊果酸包合物载药量的影响因素研究
- Author:
Peng QUAN
;
Rui LI
;
Dongfei LIU
;
Qunwei XU
- Publication Type:Journal Article
- Keywords:
Ursolic acid;
Cyclodextrins;
Complex;
Orthogonal design;
Gray relation analysis
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the substitution between the gray relation analysis( GRA) and the orthogonal design(OD) in data processing. METHODS:Take the four factors including the molar ration of drug and cyclodextrins,the agitating time and speed,and the temperature of complexation that influenced on loaded dosage of ursolic acid complex as example to analysis with 2 kinds of methods. RESULT:The result of analysis was similar by 2 kinds of methods,the molar ration of drug and the temperature of complexation were the major influence factors. CONCLUSION:When the data cannot fit to the analysis of range of OD,GRA can be used to it.
