Preparation and Stability of Tetrandrine Liposomes
- VernacularTitle:粉防己碱脂质体的制备及其稳定性研究
- Author:
Chunmei HU
;
Li ZHU
;
Junyi ZHAO
;
Chi WANG
;
Lijun PAN
- Publication Type:Journal Article
- Keywords:
Ammonium sulfate transmembrane gradient;
Film dispersion method;
Tetrandrine liposome;
Entrapment efficiency;
Stability
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To draw a comparison between the two preparative technologies of tetrandrine liposomes. METHODS: Tetrandrine liposomes were prepared with ammonium sulfate transmembrane gradient method and film dispersion method respectively. Leaking ratio,particle size,and content of phospholipid of liposomes were selected as the parameters to indicate the stability of liposomes,and the entrapment efficiency was taken as quality index to compare the two preparation technologies. RESULTS: Tetrandrine liposomes prepared with ammonium sulfate transmembrane gradient technology achieved high entrapment efficiency of 81.1% and good stability,while those prepared by film dispersion method had an entrapment efficiency of only 32.9% with poor stability. CONCLUSION: Ammonium sulfate transmembrane gradient method is feasible and superior to the film dispersion method in the preparation of tetrandrine liposome.
