The Protective and Therapeutic Effects of Metformin on Nonalcoholic Steatohepatitis in Rats
- VernacularTitle:二甲双胍对大鼠非酒精性脂肪性肝炎的防治作用
- Author:
Jian TANG
;
Fang LING
- Publication Type:Journal Article
- Keywords:
Metformin;
Nonalcoholic steatohepatitis;
Rat;
Protective and therapeutic effects
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study protective and therapeutic effects of metformin on nonalcoholic steatohepatitis(NASH) in rats. METHODS:40 SD rats were randomized into control,model,nicotinic acid,metformin group(n=10). The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion. At the same time,the control and model groups were fed with sodium carboxymethylcellulose,the other groups were fed with relative drug.The serum TG,TC,ALT,AST,FFA,TNF-? and liver tissue TG,TC,FFA were detected and with histologically. RESULTS :The model group developed NASH after 3 weeks. metformin significantly reduced TG,ALT,FFA,FBG,TNF-? of the serum and TG,FFA of the liver tissue,and ameliorated hepatocellular macrovesicular steatosis(P
