Effect of the Pegylation of Trimeric ? Peptide on It's Anti-metastasis Activity
- VernacularTitle:三聚?肽聚乙二醇化后抗肿瘤转移生物活性研究
- Author:
Jun ZHU
- Publication Type:Journal Article
- Keywords:
Trimeric ? peptide;
Pegylation;
Adhesive molecule;
Tumor cell
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effect of the polyglycol (PEG) modification of trimeric ? peptide(?3) on it’s anti-metastasis ability. METHODS: Using adhesion test to study the effects of ?3 and ?3-PEG on the adhesion of tumor cells to FN. Using artificial basal membrane to study the effects of ?3 and ?3-PEG on the invasion and recombination of basal membrane of tumor cells. RESULTS: Comparing to negative control,?3 and ?3-PEG could both inhibit the adhesion of SMMC-7721 and HCCLM6 tumor cells to FN with time-dependently(P
