The Stability of Glucosamine-?-Aminoacids-Nickel(Ⅱ) Ternary Complexes
- VernacularTitle:镍(Ⅱ)-氨基葡萄糖-?-氨基酸三元配合物的稳定性研究
- Author:
Li DONG
;
Xiangde SUN
- Publication Type:Journal Article
- Keywords:
Nickel(Ⅱ);
Glucosamine;
?-aminoacid;
Ternary complex;
Stability
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To studies on the stability of glucosamine-?-aminoacids-nickel(Ⅱ) ternary complexes(GANTC). METHODS: The formation constant of GANTC were determined at (25?0.1) ℃,I=0.1 mol?L-1 KNO3 by pH method. RESULTS: The formation constant of GANTC were Gly 13.73(7.33),Pro 13.97(7.12),Ser 13.15(7.07),Val 13.46(6.84),iLe 13.55(6.88),Phe 13.13(6.93) and Met 13.17(7.18). CONCLUSIONS: The two biologically active ligand,?-aminoacid and glucosamine accommodate each other when coordinated to nickel(Ⅱ) ion. The formation constant of the ternary complexes linearly increase with the increase of protonation constant of aminoacid. Linear free energy relationship does exist in the presence of ternary system.
