Preparation and Quality Control of Diclofenac Sodium Hollow Suppository
- VernacularTitle:双氯芬酸钠中空栓的制备及质量控制
- Author:
Hui XIONG
;
Yonggang CHEN
;
Zhengzheng LI
- Publication Type:Journal Article
- Keywords:
Diclofenac sodium;
Hollow suppository;
Preparation;
Ultraviolet spectrophotometry;
Quality control
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare diclofenac sodium hollow suppository and establish its quality control. METHODS: The hollow type suppository was prepared with mixed fatty glyceride as the base; the content of diclofenac sodium was deter-mined by ultraviolet spectrophotometry. RESULTS: The linear range of diclofenac sodium was 5～25 ?g?mL-1(r=0.999 7),with an average recovery rate of 102.04%(RSD=1.08%). CONCLUSION: The preparation technology of diclofenac sodium hollow suppository is simple and feasible,and the quality of the suppository is stable and controllable.
