Identification of the Alkali Degradation Compounds of Voriconazole by LC-MS-MS
- VernacularTitle:LC-MS-MS法分析伏立康唑的碱降解产物
- Author:
Sheping XIE
- Publication Type:Journal Article
- Keywords:
Vorionazole;
LC-MS-MS;
Degradation compounds
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish an LC-MS-MS method for the rapid analysis of the degradation compounds of vorionazole. METHODS: The degradation compounds and the control substance of vorionazole were compared in respect of relative molecular mass,fragments,spectra characteristics using LC-MS-MS technology. RESULTS: Vorionazole and its degradation compounds could be effectively isolated. The two main degradation compounds were the isomers of 4-ethyl-5-fluoropyrimidine. CONCLUSION: The analytic method is rapid,sensitive,and specific,and it can be applied to predicate the structure of the degradation compounds of vorionazole.
