Determination of Sulbactam Pivoxil and the Related Substances in Amoxicillin Sulbactam Pivoxil Dispersible Tablets by HPLC-DAD
- VernacularTitle:HPLC-DAD法测定阿莫西林舒巴坦匹酯分散片中舒巴坦匹酯含量及有关物质
- Author:
Xiaoya FU
- Publication Type:Journal Article
- Keywords:
HPLC-DAD;
Amoxicillin sulbactam pivoxil dispersible tablets;
Content determination;
Related substances
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish an HPLC-DAD method for the determination of sulbactam pivoxil and the related substnaces in amoxicillin sulbactam pivoxil dispersible tablets. METHODS: The chromatographic column was Hypersil BDS with mobile phase consisted of potassium dihydrogen phosphate solution∶acetonitrile (40∶60) at a flow rate of 1.0 mL?min-1. The detector was diode array detector (DAD) at a detection wavelength of 204 nm and spectrum range of 300～190 nm. The injection volume was 10 ?L. RESULTS: The linear range of sulbactam pivoxil was 119.83～119 8.3 ?g? mL-1(r=0.999 9),with an average recovery rate of 98.7%(RSD=0.65%). The content of the related substances was 1.02%～1.10%. CONCLUSION: The method is simple and accurate,and it can be used for the quality control of amoxicillin sulbactam pivoxil dispersible tablets.
