Determination of Dissolution of Warfarin Potassium Tablets by UV Spectrophotometry
- VernacularTitle:紫外分光光度法测定华法林钾片的溶出度
- Author:
Yingshun JIN
- Publication Type:Journal Article
- Keywords:
Warfarin potassium tablets;
Dissolution;
UV spectrophotometry
- From:
China Pharmacy
2005;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a method for the determination of dissolution of warfarin potassium tablets. METHODS: The dissolution of warfarin potassium tablets was determined by UV spectrophotometry at a detection wavelength of 283 nm with 0.1 mol?L-1 hydrochloric acid as the solvent at a volume of 900 mL. The rotation speed was 50 r?min-1 and the sampling time was 30 min. RESULTS: The method showed a good linear relationship in the range of 5～30 ?g?mL-1(r=0.999 9). The average recovery was 100.53%(RSD=0.69%). The dissolutions of 3 batches of samples were all above 90%. CONCLUSION: The method is simple,accurate and reliable,and it can be applied for the determination the dissolution of warfarin potassium tablets.
