Two Different Doses of Cyclosporine for Patients After Renal Transplantation:Clinical Controlled Study
- VernacularTitle:肾移植术后应用2种不同剂量环孢素A的临床对照研究
- Author:
Li WANG
;
Yiping LU
;
Ming SHI
;
Xi XIE
;
Jia WANG
;
Keshi TANG
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Cyclosporine A;
Mycophenolate Mofetil
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To discuss whether a reduced dose of CsA was allowed yet without increase risk of rejection, and whether the incidence of CsA-related side effects be reduced while the curative effects be enhanced by combined use of Cyclosporine (CsA), prednisone and Mycophenolate Mofetil (MMF) in patients after renal transplantation. METHODS: In this comparative study, 213 renal allograft recipients receiving routine dose of CsA were compared with 176 cases receiving low dose CsA. RESULTS: The two groups showed no significant differences in renal function, incidence of rejection and human/kidney survival rate. However, the low dose CsA group showed a better total curative efficacy and significantly fewer incidences of ADRs. CONCLUSION: CsA, MMF and Pred used concomitantly in patients after renal transplantation allows for a reduced dose of CsA yet without increase the risk of acute rejection if with enough dose of MMF.
