Clinical Research of Therapeutic Drug Monitoring for CsA in Allogeneic Hematopoietic Stem Cell Transplantation
- VernacularTitle:环孢素A峰浓度监测在异基因干细胞移植术中的意义研究
- Author:
Hua OUYANG
;
Meifang WANG
;
Zheng WANG
;
Quanyi LU
- Publication Type:Journal Article
- Keywords:
Allogeneic hematopoietic stem cell transplantation;
Cyclosporine A;
C2
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical role of two-hour(C2)of CsA in allogeneic hematopoietic stem cell transplantation.METHODS:The whole blood CsA concentration of 9 patients of C0 and 12 of C2 were determined by FPIA method . RESULTS: The satisfactory immunosuppressive concentration was found as follow: C0 was 200～400 ?g?L-1and C2 was 500～700 ?g?L-1.Both C0 and C2 could predict the acute rejection and side-effects,but C2 is more effective.CONCLUSION:The factors that affect the whole blood concentration of CsA were complex. CsA blood concentration monitoring can be used to guide rational use of CsA,but C2 is more effective than C0.
