In Vitro Antibacterial Activity of Pazufloxacin Combined with Cefoperazone/Sulbactam Against Multidrug Resistant Bacteria
- VernacularTitle:帕珠沙星与头孢哌酮/舒巴坦联用对金葡菌等多重耐药菌体外抗菌效果的研究
- Author:
Sheng LOU
;
Junrong ZHU
;
Yixing SHI
- Publication Type:Journal Article
- Keywords:
Pazufloxacin;
Cefoperazone/Sulbactam;
Coadministration;
FIC
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To valuate the antibiotic effects in vitro of Pazufloxacin combined with Cefoperazone/Sulbactam against 90 common pathogenic bacteria from hospital acquired infection. METHODS: The protocol was designed by checkerboard method. The MIC of two antibiotics alone or in combination against 90 strains (including 30 staphylococcus aureus, 30 Escherichia colis, 30 Pseudomonas aeruginosas) were detected by broth dilution method and the FIC index was calculated according to MIC values. RESULTS: The MIC of Pazufloxacin combined with cefoperazone/sulbactam against 90 strains was reduced significantly. The percentage of the FIC index maintained at less than 0.5, 0.5～1, 1～2, above 2 were 60.7%～80.0%, 20.0%～33.3%, 3.3%～6.6%, and 0% respectively. CONCLUSION: The antibiotic activity of Pazufloxacin combined with cefoperazone/sulbactam against 90 common iatrogenic strains from hospital acquired infection was enhanced significantly. Their antibacterial action in vitro was characterized by synergism and additive action instead of antagonistic effect.
