Correlation between TAFI and blood fat and coagulation in the process of atherosclerosis
- VernacularTitle:大鼠动脉粥样硬化形成中凝血酶活化的纤溶抑制剂与血脂及凝血的关系研究
- Author:
Liyan LIU
;
Xiangqun LIU
;
Huanqin CHEN
;
Xiaoan CHEN
- Publication Type:Journal Article
- Keywords:
Arteriosclerosis;
Thrombin-activatable fibrinolysis inhibitor;
Endothelial injury
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the relationship between the thrombin-activatable fibrinolysis inhibitor (TAFI) level in plasma and atherosclerosis, the TAFI level in plasma and blood fat and blood clotting index.METHODS: Totally 40 healthy male Wistar rats were randomly divided into 4 groups (n=10), control group, high lipid group, high lipid +vitamin D3 overload group, and high lipid +vitamin D3+endothelium injure group by treating the animals with normal diet, high lipid, high lipid+ vitamin D overload, and high lipid+vitamin D overload+endothelium injury, respectively, for inducing three stages of AS in rats. Then, the total cholesterol (TC), total triglyeride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and prothrombin time (PT), activated partial thromboplasin time (APTT), fibrinogen (Fib), the activity of TAFI were measured.RESULTS: TC, TG, LDL-C, Fib and the activity level of TAFI in plasma in three model groups increased gradually compared with the control (P
