Changes of Transepidermal Water Loss (TEWL) in Psoriatic Plaques during D-PUVA Therapy.
10.5021/ad.2001.13.1.7
- Author:
Dae Hun SUH
;
Tae Eun KWON
;
Sang Duck KIM
;
Seok Bum PARK
;
Oh Sang KWON
;
Kyu Han KIM
;
Kyoung Chan PARK
- Publication Type:Original Article
- Keywords:
TEWL;
PUVA
- MeSH:
Erythema;
Humans;
Psoriasis;
PUVA Therapy;
Skin;
Water*
- From:Annals of Dermatology
2001;13(1):7-11
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Psoriatic lesions have reduced water-holding capacity and show increased transepidermal water loss (TEWL). The effect of D-PUVA therapy, which combines topical calcipotriol and PUVA therapy, on epidermal barrier function has not yet been evaluated. OBJECTIVE: The purpose of this study was to verify the change of TEWL in lesional and normal skin according to D-PUVA therapy in psoriasis patients. METHODS: TEWL was measured consecutively by TEWAMETER TM210®, in 13 psoriasis patients who received D-PUVA therapy. Clinical grading was done according to psoriasis severity index (PSI). RESULTS: TEWL of psoriatic lesion decreased as D-PUVA continued. TEWL of normal-looking skin gradually increased, although the increase was trivial. Clinical grading of scale and in-filtration followed the pattern of PSI in the decrease of TEWL, while that of erythema did not. CONCLUSION: In psoriatic plaques, TEWL was decreased according to the improvement. In normal-looking skin, D-PUVA therapy caused only a little effect on TEWL.
