Preparation and in Vitro Release of Irinotecan Hydrochloride Liposome
- VernacularTitle:盐酸伊立替康脂质体的制备及体外释药特性研究
- Author:
Jianjian ZHANG
- Publication Type:Journal Article
- Keywords:
Irinotecan hydrochloride;
Liposome;
In vitro drug release
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare irinotecan hydrochloride liposome and study its drug release profile in vitro.METHODS:Irinotecan hydrochloride liposome was prepared by ammonium sulfate gradient method.Orthogonal test was conducted to optimize the formula and preparation techniques of irinotecan hydrochloride liposome,and the release of it in vitro was investigated by dialysis method.RESULTS:The entrapment efficiency(EE) of the prepared liposome was as high as 75.4%.The optimized formula was as follows:the ratio of lipid to cholesterol was 2∶1;the concentrations of ammonium sulfate was 0.20 mol?mL-1;the incubation temperature was 50 ℃ and the ratio of drug to lipid was 1∶10.The study proved that the liposome could retard drug release in vitro,at a release rate of 8.09% at 1 h and 64.2% at 9 h.CONCLUSION:The irinotecan hydrochloride liposome had high EE and characterized by slow drug release.
