Effects of LYS Polysaccharides on Learning and Memory as Well as Monoamine Neurotransmitter Content in SAMP8 Mice's Brain
- VernacularTitle:龙眼参多糖对SAMP8学习记忆及脑组织单胺类神经递质含量影响的研究
- Author:
Zhongshi HUANG
;
Xing LING
;
Shijun ZHANG
;
Yang JIAO
;
Weizhe JIANG
;
Renbin HUANG
- Publication Type:Journal Article
- Keywords:
LYS polysaccharides;
Animal experiment;
Learning and memory abilities;
Monoamine neurotransmitter content
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of LYS polysaccharides on learning & memory and monoamine neurotrans-mitter content in SAMP8 brain.METHODS:50 6-month-old SAMP8 mice were randomized to 5 groups(10 in each group):SAMP8 group,huperzine A control group,low-,mid-and high-dose groups of polysaccharides.Another 10 6-month-old SAMR1 mice were assigned to normal control group.After medication for 40 days,the learning and memory abilities of mice in each group were detected with Morris water maze method.The norepinephrine(NE),dopamine(DA) and 5-HT contents in brain were determined by HPLC.RESULTS:The learning and memory abilities of SAMP8 group decreased significantly,and the NE,DA and 5-HT contents in brain decreased significantly compared with normal group(P
