Pharmacokinetics and Serum Fingerprints of Decoction for Puerperal Blood Stasis
- VernacularTitle:生化汤药动学及其血清指纹图谱研究
- Author:
Junfen ZENG
;
Jinchun SONG
;
Jianwu LU
- Publication Type:Journal Article
- Keywords:
Decoction for Puerperal Blood Stasis;
Pharmacokinetics;
Serum fingerprint;
Ferulaic acid
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacokinetics and serum fingerprints of Decoction for Puerperal Blood Stasis at different time.METHODS:The content of Ferulaic acid(FA) was determined by HPLC.The pharmacokinetic study was carried out.The active constituent in the Decoction for Puerperal Blood Stasis was analyzed based on the serum fingerprints of FA.RESULTS:The distribution and metabolism of FA in rabbits after oral administration of Decoction for Puerperal Blood Stasis assummed two compartment model.The fingerprints between serum at different time and blank serum showed significant differences.CONCLUSION:The content change of FA monitored with serum fingerprints was in line with the rule of pharmacokinetics of FA in Decoction for Puerperal Blood Stasis.The fingerprints can be applied to clarify the pharmacokinetic characteristics,the pharmacological action and the action mechanism of Decoction for Puerperal Blood Stasis.
