Investigation of Dissolution of DEHP in Packaged Infusion Sets of Paclitaxel Injection
- VernacularTitle:紫杉醇注射液配套输液器中邻苯二甲酸二辛酯的溶出性考察
- Author:
Enjuan ZHANG
;
Lin CHEN
;
Jian CAO
- Publication Type:Journal Article
- Keywords:
Paclitaxel injection;
Packaged infusion sets;
DEHP;
Investigation of dissolution
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the dissolution of DEHP in PVC infusion set and the packaged infusion sets of the Paclitaxel injection so as to evaluate the safety of clinical infusion sets for paclitaxel.METHODS:The packaged infusion sets of Paclitaxel injection were collected from 9 Three-A grade hospitals in Chongqing.Paclitaxel injections were prepared as per actual concentration needed by the clinic and dripped through eight different infusion sets(in which 7 were packaged infusion sets) for 3 h.The peak area of the collected solution was measured and its content was determined by HPLC,and the effect of infusion time on the dissolution of DEHP was investigated as well.RESULTS:The dissolution of DEHP dripped through eight infusion sets were 1 408,9 393,6 576.5,2 412.6,8 194.4,0,8 477.2,and 8 037.4 ?g,respectively.The dissolution increased with the prolonging of infusion time.CONCLUSION:At present,the majority of packaged infusion sets of Paclitaxel injection were made form PVC materials.The safe medication of Paclitaxel can't be ensured for the dissolved DEHP can enter the blood directly,thus its hazardness should be given great attention.
