A Clinicopathologic Study on Nevus Sebaceus.
10.5021/ad.2001.13.1.32
- Author:
Soyun CHO
;
Kyu Kwang WHANG
;
Jeong Hee HAHM
- Publication Type:Original Article
- Keywords:
Nevus sebaceus of Jadassohn;
Clinical and histopathological study
- MeSH:
Apocrine Glands;
Dermis;
Epidermis;
Female;
Hair Follicle;
Head;
Humans;
Hyperplasia;
Incidence;
Nevus*;
Nevus, Sebaceous of Jadassohn;
Papilloma;
Parturition;
Scalp;
Sebaceous Glands
- From:Annals of Dermatology
2001;13(1):32-38
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Nevus sebaceus of Jadassohn is a complex anomaly involving the epidermis, dermis, apocrine glands and hair follicles, as well as the sebaceous glands, and a variety of benign and malignant tumors and neurologic abnormalities may be associated with it; however, only a few studies on it have been reported in the Korean literature. OBJECTIVE: The objectives of this study was to document clinical and histopathologic features of nevus sebaceus in Koreans and compare them to those in the previously reported studies. METHOD: Clinical records and histopathology of 53 cases of nevus sebaceus diagnosed at Ewha Womans University Tongdaemun Hospital during a period of 18 years were reviewed and analyzed. RESULTS: The average incidence rate of nevus sebaceus among new patients was 0.03%. The male-to-female ratio was 1.04 and the average age at visit, 16.5 years. The lesions had been present since birth or had developed before age 10 in 85% of the cases. A11 lesions were situated on the head, and the most common site was the scalp. Linear 1esions (20.8%) were mostly facial lesions. Histopathologically, the incidence of sebaceous and apocrine glandular hyperplasia was most notable in the 13-18 and over-18 age groups. The sebaceous glands showed small punched out defects or "holes" in 24.5%; ectopic apocrine glands were found in 24.5 %. Mature hair follicles were absent or greatly reduced in number in 75.5%. Acanthosis nigricanslike pattern of acanthosis and mild papillomatosis were the dominant changes in the epidermis. Hyperplasias and neoplasms were associated in 15.1%, which included 5 cases of primitive follicular induction and 1 trichoblastoma. CONCLUSION: In this series, no examples of malignant neoplasms were identified; however, an early total excision before age 13 is recommended since a variable "deficit malformation" of the follicles with hyperplasia of the epidermis and sebaceous glands becomes more prominent after that age.
