Effects of Yichan decoction(抑颤汤) on dopamine receptors and neurotensin in cerebral tissue of rats with Parkinson's disease
- VernacularTitle:抑颤汤对帕金森病大鼠脑内多巴胺受体和神经降压素含量的影响
- Author:
Minghui YANG
;
Haiming WANG
;
Yi LIU
;
Yongqi DOU
- Publication Type:Journal Article
- Keywords:
Parkinson′s disease;
mechanism of action;
Yichan decoction
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of Yichan decoction(抑颤汤) in treatment of Parkinson′s disease(PD).Methods A PD rat model was made by direct injection of 6-hydroxydopamine(6-OHDA) into the brain to destruct the compact part of substantia nigra(SNC).One hundred Sprague-Dawley(SD) rats were randomly divided into a normal control group,a PD model group and a Yichan decoction treatment group and they were treated for 8 weeks.The rats′ behavior pattern changes were observed before treatment and from 5th weeks after treatment.The changes in the dissociation constant(Kd) and maximum number of binding sites(Bmax) of dopamine(DA) receptors,and neurotensin-immunoreactive(NT-IR) in substantia nigra after treatment were determined by using the technique of radioimmunity.Results Yichan decoction could markedly improve the rotation of PD model rats and decrease the average number of rotation from(349.56?62.28) circle/40 minutes to(61.63?17.93) circle/40 minutes(P
