Radiosensitization Effect of Docetaxel versus Sodium Glycididazole for Nasopharyngeal Carcinoma
- VernacularTitle:多西他赛与甘氨双唑钠在鼻咽癌放射治疗中增敏疗效比较
- Author:
Jize ZENG
;
Hang ZHOU
;
Xiao LIU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Docetaxel;
Sodium glycididazole;
Radiotherapy
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the radiosensitization effect of docetaxel versus sodium glyci-didazole.METHODS:A total of 105 patients with intermediate or advanced stage nasopharyngeal carcinoma were randomly assigned to receive docetaxel 40 mg once a week plus radiotherapy or sodium glycididazole 1 000 mg three times a week(Monday,Wednesday and Friday) plus radiotherapy for a total of 7 weeks,or radiotherapy only(control group).RESULTS:There were significant differences between docetaxel group or sodium glycididazole group and control group in sensitization efficiency and radiation dose on tumor regression(P0.05).CON-CLUSION:Lower dose docetaxel is better than sodium glycididazole in radiosensitization efficiency for advanced nasopharyngeal carcinoma,especially in controlling the metastasis,yet it has minimal side effect.
