Effect of Somatostatin on the liver iryury in acute hemorrhagic necrotizing pancreatitis in rats and its mechanism
- VernacularTitle:生长抑素对急性出血坏死性胰腺炎肝损伤的作用机制
- Author:
Zhao ZHANG
;
Gang ZHAO
;
Dan WANG
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis,Acute Necrotizing;
Liver/pathol;
Somatostatin;
Reseptor,Toll;
NF-?B
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects and mechanisms of somatostatin on liver injury in acute hemorrhagic necrotizing pancreatitis(AHNP) in rats.Methods Murine model of AHNP was established by retrograde injection of artificial bile into the biliopancreatic duct.The animals were divided into sham operation group(S group), AHNP saline injection group(AHNP group), and AHNP octreotide treated group. TLR2,4 mRNA expressions and NF-?B expressions in the liver tissue at 3,6 and 12h after operation were measured.Results TLR2,4 mRNA in liver tissue in the AHNP group began to rise at 3h,and peaked at 12 h(P
