The significance of activation of splenic nuclear factor ?B in rats with acute pancreatitis
- VernacularTitle:急性胰腺炎大鼠脾脏核因子?B表达的意义
- Author:
Zhanfeng CHEN
;
Qilong CHEN
- Publication Type:Journal Article
- Keywords:
Pancreatitis/pathol;
Spleen;
Inflammatory Mediator;
Nuclear Factor ?B
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the spleen in the pathogenesis of acute pancreatitis(AP). Methods The studied rats were divided randomly into four groups:Sham operation group, splenectomy group, AP group and AP with splenectomy group.The rats were sacrificed at 3h,6h and 12h after operation, and spleen and pancreas were removed for examination. Light microscopy was used to examine pancreatic tissues for pathologic change and to assess pathology score. Immunohistochemical method was used to observe the activity of splenic NF-?B(p65) in the rats with AP.Results The pancreas pathology score in the AP with splenectomy group was significantly lower than that in AP group at 6h(7.83?0.753vs 9.67?1.211) and 12 h (9.67?0.816 vs13?0.894) after operation (P
