Effects of ethanol on HBV gene mutations in patients with chronic hepatitis B by gene chip
- VernacularTitle:基因芯片检测乙醇对慢性乙型肝炎患者乙肝病毒多位点基因突变的研究
- Author:
Jian CHEN
;
Jianmin XU
;
Min WANG
;
Fuguo LIU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Gene mutation;
Ethanol
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study ethanol influence on gene mutations of HBV DNA and to offer testimony for clinical diagnosis and treatment of chronic hepatitis B.METHODS: 85 patients with chronic hepatitis B were divided into alcoholic group and non-alcoholic group.Gene chip technique was used to detect gene mutations located in Pre-C nt G1896A and nt A1814C,basal core promoter(BCP) nt A1762T and nt G1764A,P nt C528A and nt T552C.RESULTS: The mutation frequency on BCP nt A1762T and nt G1764A in alcoholic group was significantly higher than that in non-alcoholic group(P0.05).CONCLUSION: Ethanol stimulates HBV gene mutations on BCP nt A1762T and nt G1764A,enhances HBV DNA replication and gene expression,deteriorates the state of the illness.
