Septic shock down-regulates L-arginine /NOS/NO pathway of platelet and aortic intima in rats
- VernacularTitle:感染性休克下调大鼠血管内皮和血小板L-精氨酸/一氧化氮通路
- Author:
Yuying CUI
;
Chaoshu TANG
;
Bin GENG
;
Haolou FENG
- Publication Type:Journal Article
- Keywords:
Shock,septic;
Tunica intima;
Blood platelets;
Nitric oxide;
Nitric-oxide synthase;
Arginine
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate alteration and cross link of the aortic and platelet endogenous L-arginine/NOS/NO pathway induced by septic shock.METHODS: The septic shock model was made in rats by caecal ligation and puncture.NO-2 /NO-3 production released from aortic and platelet was measured with Greiss assay.NOS activity and L-arginine transport activity were detected by isotope tracer method.RESULTS: Both in early and late stage of septic shock,NO-2 /NO-3 production,NOS activity,and the L-arginine transport from the aorta intima and platelets were obviously decreased,while those of the aorta media and adventitia were obviously increased(P0.05 and P
