Protective Effects of Two Kinds of Fasudil Hydroehloride Injections on Experimental Cerebral Ischemia of Rats
- VernacularTitle:2种盐酸法舒地尔注射液对大鼠实验性脑缺血保护作用的研究
- Author:
Yingmei FU
;
Guangren LIAO
- Publication Type:Journal Article
- Keywords:
Fasudil hydroehloride injections;
Experimental cerebral isehemia;
Rat;
Neurological function;
Protective effect
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare the protective effects of two fasudil hydroehloride injections (trade name: Yililu vs. Chuanwei) on experimental cerebral ischemia of rats. METHODS: A total of 60 SD rats were randomly divided into sham opertion group, model group, Yililu group, Chuanwei high dose group, and Chuanwei low dose group. Cerebral ischemia model was made in each group for the observation of the effects of fasudil hydroehloride injections on the neuralogical function, cerebral infarction size and the pathomorphology of brain tissues. RESULTS: As compared with model group, two kinds of the fasudil hydroehloride injections at the same dose identically decreased the score of neurological function as well as the cerebral infarction size, and lessened the degree of the pathomorphological change of brain tissues (P0.05). CONCLUSION: The two kinds of fasudil hydroehloride injections showed an equivalent protective effect on the damage of experimental cerebral ischemia.
