Clinical Efficacy of Recombined Human Keratinocyte Growth Factor Variant for Alkali Burn in Rabbit
- VernacularTitle:重组人角质细胞生长因子异构体对兔角膜碱烧伤的疗效观察
- Author:
Wei LI
;
Yuanda ZHOU
- Publication Type:Journal Article
- Keywords:
Recombined human keratinocyte growth factor variant;
Cornea;
Alkali burn;
Rabbit;
Neovascularization;
Wound healing
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of recombined human keratinocyte growth factor variant (K102) on corneal alkali burn in rabbit. METHODS: 60 New Zealand rabbits were randomized to 5 groups. Corneal alkali burn models were made and in the left eyes of the rabbits with 1 mol?L-1 NaOH solution. Then the trial groups (groups A, B and C) were treated with 0.5, 0.25, 0.125 mg?mL-1 K102 eye drops, respectively; group D (positive control group) with bFGF eye drops, and group E (negative control group) with solvent of K102 eye drops. The rate of corneal reepithelialization and the area of neovascularization (CNV) were observed under microscope. RESULTS: Within 24 h, the corneal epithelium growth rate in the trial groups (A, B and C) were 1.52, 1.57 and 1.46 mm2?h-1, respectively, which were significantly different as compared with negative control group (0.98 mm2?h-1) (P
