Optimization of the Formulation of Film Coating of Metformin Hydrochloride Sustained-release Pellets in Compound Glipizde Extended-release Capsules
- VernacularTitle:复方格列吡嗪缓释胶囊中盐酸二甲双胍缓释微丸薄膜衣处方的筛选
- Author:
Xiaoming LI
;
Xiaoli WANG
;
Jicheng LIU
- Publication Type:Journal Article
- Keywords:
Metformin hydrochloride;
Sustained-release pellets;
Film coating;
Release rate in vitro
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize the formulation of metformin hydrochloride sustained-release pellets prepared using film coating technology. METHODS: Taking release rate in vitro as index, the formulation of the film-coat was prelimilarily selected using one facotr sreening method and optimzed using orthogonal test. The release rate of the prepared metformin hydrochloride sustained-release pellets was determined and compared with that metformin hydrochloride pellets. RESULTS: The optimized formulation was as follows: the film material of Eudragit NE 30D and Eudragit L 30D55 at a ratio of 10∶1 were added with 40% talcum powder and 0.25% sodium dodecyl sulfate. The release rate of the metformin hydrochloride sustained-release pellets was higher than that of metformin hydrochloride pellets. CONCLUSION: The metformin hydrochloride sustained-release pellets were up to the requirements of sustained release and characterized by 24h continuous drug release.
