Determination of Telmisartan and Hydrochlorothiazid in Telmisartan Compound Preparation by Dual Wavelength TLC
- VernacularTitle:双波长薄层扫描法测定复方替米沙坦制剂中主药的含量
- Author:
Mingtao TAO
;
Xiangan YU
- Publication Type:Journal Article
- Keywords:
TLC;
Telmisartan;
Hydrochlorothiazid;
Content determination
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To determine the contents of telmisartan and hydrochlorothiazid in compound telmisartan preparation by TLC. METHODS: Using acetic ether-chloroform-methanol-glacial acetic acid (50∶40∶10∶5) as developer, the contents of telmisartan and hydrochlorothiazid were determined by dual wavelength thin layer chromatography with the reflection linearity parameter SX=7 and slit=1.0 mm?5.0 mm. The determinated wavelength of telmisartan was as follows: ?R=365 nm and ?S=305 nm; the wavelength of hydrochlorothiazid was as follows: ?R=370 nm and ?S=275 nm. RESULTS: The linear ranges of telmisartan and hydrochlorothiazid were 1.114～5.57 ?g (r=0.999 6) and 3.664～18.32 ?g (r=0.999 8), respectively, and the average recovery rates of telmisartan and hydrochlorothiazid were 97.95% (RSD=1.30%) and 98.32% (RSD=1.13%), respectively. CONCLUSION: The method is simple, rapid, accurate and it can be used for the quality control of compound telmisartan preparation.
