Antiproliferative Effect of Curcumine on Human Prostatic Hyperplasia Cell Line BPH1
- VernacularTitle:姜黄素抑制人前列腺增生细胞BPH1增殖的研究
- Author:
Zhiqiang CHEN
;
Zengnan MO
- Publication Type:Journal Article
- Keywords:
Curcumin;
Prostatic hyperplasia;
Apoposis
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the inhibitory effect of Curcumine on the proliferation and gene expression of human prostatic hyperplasia cell line BPH1. METHODS: MTT were used to examine the cell growth of Human prostatic hyperplasia cell line BPH1 after treated with different doses of Curcumine. The expressions of PCNA mRNA and Bcl-2 at transcription were detected by RT-PCR. RESULTS: Curcumine inhibited cell growth time or dose-dependently and down-regulated the expressions of PCNA and Bcl-2 in BPH1 cells dose-dependently within 24 h after being treated by Curcumin.CONCLUSI-ON: The antiproliferative effect of Curcumine on BPH1 might be associated to the downregulation of PCNA and Bcl-2 levels.
