Effect of Extracts of Paederia Scandens on Acute Gouty Arthritis Induced by Monosodium Urate Crystals in Rats
- VernacularTitle:鸡矢藤提取物对尿酸钠晶体诱导大鼠急性痛风性关节炎影响的研究
- Author:
Ying MA
;
Haiyan YAN
;
Mei LIU
;
Lanlan ZHOU
- Publication Type:Journal Article
- Keywords:
Extracts of Paederia scandens;
Sodium urate crystal;
Gouty arthritis;
Interleukin-1?;
TNF-?
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of the extracts of Paederia scandens (EPS) on acute gouty arthritis induced by monosodium urate in rats. METHODS: Monosodium urate crystals were used to establish gouty arthritis model in rats, with ankle joints' swelling degree at different time after modeling measured using paw volume measuring meter and gaits of rats scored at 24h after modeling. Pathological changes of articular tissues of rats were observed with HE staining and TNF-? and IL-1? levels were monitored by Radioimmunoassay. RESULTS:EPS could significantly inhibit joint swelling of rats and improve the gaits; histopathologically, EPS could abate tissue swelling of ankle joints, reduce inflammatory cell infiltration of articlar tissues and improve the pathological changes of synovial membranes. Radiommunoassay revealed that EPS could reduce levels of TNF-? and IL-1? in rats' synovial membranes. CONCLUSION:EPS have remarkable efficacy in improving symptoms of acute gouty arthritis induced by monosodium urate crystals in rats, which might be related to its inhibition on levels of IL-1? and TNF-?.
