Adverse Drug Reactions in Hematological System Induced by Antituberculosis Drugs:Literature Review of 441 Cases
- VernacularTitle:441例抗结核药引起血液系统不良反应文献分析
- Author:
Qian WANG
;
Jinhong CHEN
;
Qin HAN
;
Yuefeng ZHANG
- Publication Type:Journal Article
- Keywords:
Antituberculosis drugs;
Hematological system;
Adverse drug reactions;
Literature;
Analysis
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the abnormality in hematological system induced by antituberculosis drugs so as to promote the rational use of drugs in the clinic.METHODS:The 441 case reports on abnormality in hematological system induced by antituberculosis drugs retrieved from Chinese medical science periodicals from Jan 1990 to Apr 2007 collected in CHKD periodicals knowledge base in China hospital digital library were analyzed statistically.RESULTS:A total of 15 antibuberculosis drugs were involved in the ADR cases,leading the list were rifampicin,ciprofloxacin and isoniazide,which resulted in a total of 211 ADR cases.Leukopenia was the chief clinical manifestation.CONCLUSIONS:It is essential for clinical practitioners master the distribution patterns of ADR in hematological system caused by antituberculosis drugs so as to promote medication safety.
