The experiment study of hypoxia inducible factor-1? expression after spinal cord injury in rats
- VernacularTitle:大鼠脊髓损伤后HIF-1?基因的表达
- Author:
Yang LIU
;
Yanling HAN
;
Ji LIU
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Spinal cord injury;
RT-PCR;
Hypoxia inducible factor-1?(HIF-1?);
Immunohistochemistry
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).In spinal cord tissues of injury groups,the level of HIF-1? mRNA began to elevate at 3h after injury and reached the maximize on 3d,then it began to decline and returned to the basal level on 14d;the HIF-1? expression showed a time-dependent difference as followed: It began to increase at 3h after injury,peaked on 1d,then gradually decreased,and recovered to the normal level on 14d after injury.Conclusion The result suggested that hypoxia circumstance can enhance the stability of HIF-1? and the transcription of HIF-1? mRNA,and the time-dependent expression of HIF-1? and HIF-1? mRNA can be used to help the diagnosis of SCI and estimation of injury time.
