Relationship between CRP and CK-MB among Acute and Stable COPD Patients
- VernacularTitle:慢性阻塞性肺病不同病情患者血清C反应蛋白和磷酸肌酸激酶同工酶水平
- Author:
Fei XU
;
Xin HONG
;
Hongbing SHEN
- Publication Type:Journal Article
- Keywords:
COPD;
CRP;
CK-MB;
PaO2;
Epidemiology
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between CRP and CK-MB among acute and stable patients with COPD in Nanjing city. Methods Using case-control design, 81 COPD patients and 71 normal controls were selected. Both fasting venous and arterial blood samples were collected for COPD patients at the acute and the stable stage separately, while fasting venous blood samples were collected for controls during medical examination. The concentrations of CRP, CK-MB or PaO2 of all blood samples were examined. Results The concentration of CRP and CK-MB were significantly higher among stable COPD patients (7.18?5.62, 10.92?5.33; respectively) than those among controls(3.00?0.91, 3.11?1.46; respectively), while acute patients (51.22?24.53,30.06?16.68; respectively) got much higher concentration of CRP and CK-MB than stable patients did. However, PaO2 was significantly higher among stable COPD patients than that among acute patients. For acute COPD patients, the concentration of CK-MB positively correlated with CRP, while PaO2 negatively correlated with CRP and CK-MB separately. Conclusions CRP and CK-MB were sensitive predictors of COPD status to the transition from stable to acute stage of COPD, and both negatively correlated with PaO2 among these sample COPD patients.
