Recent advances in the study of G protein-coupled receptor 40/free fatty acid receptor 1
- VernacularTitle:G蛋白偶联受体40/游离脂肪酸受体1的研究进展
- Author:
Yuan TIAN
;
Lulu CHEN
- Publication Type:Journal Article
- Keywords:
G protein-coupled receptor 40;
Fatty acids,nonesterified;
Islets of Langerhans
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Free fatty acids(FFAs) provide an important energy source and also act as signaling molecules.Medium to long-chain free fatty acids can activate the intracellular signal pathways in the pancreatic ?-cells and play a role in regulating insulin secretion as an extracellular signal molecular via binding to the FFA receptor G protein-coupled receptor 40(GPR40). Furthermore,GPR40 is associated with several biological effects including cell proliferation and antiapoptosis of nerve cells.GPR40 act an important role in the connection of obesity and diabetes or cancers.GPR40 will probably become a novel kind of antidiabetic and anticancer drugs.
