Positive inotropic action of urocortin on isolated heart tissues of the spontaneously hypertensive rat
- VernacularTitle:尿皮素对高血压大鼠离体心肌的正性肌力效应
- Author:
Zhongning ZHU
;
Leiming REN
;
Ding ZHAO
;
Kui QIN
- Publication Type:Journal Article
- Keywords:
Urocortin;
Myocardium;
Spontaneously hypertensive rat;
Myocardial contraction
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of urocortin(Ucn) on the isolated heart tissues of spontaneously hypertensive rat(SHR).METHODS: Effects of Ucn on contractile force and heart rate were observed in the SHR and Wistar rat right atrium,left atrium and right ventricle strip.RESULTS: Ucn(1-10 nmol/L) concentration-dependently increased the contractile force in the SHR and Wistar rat isolated right atrium.Ucn increased the contractile force in the SHR by(31.1?14.9)% at 3 nmol/L and by(65.7?22.4)% at 10 nmol/L,and its inotropic effect was significantly greater than that in Wistar rat(P
