Inhibitory Effect of Mifepristone-releasing Implants on Endometriosis in Rats
- VernacularTitle:米非司酮皮下埋植剂抑制大鼠异位子宫内膜的效果观察
- Author:
Hongfan SUN
;
Jing YANG
;
Lina TANG
;
Li WU
;
Cunxian SONG
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Implant;
Endometriosis;
Rat;
Inhibition ratio
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy of mifepristone-releasing implants for endometriosis in rats.METHODS:Mifepristone-releasing implants(one tube at 0.75,1.5,and 3.0 cm in length,or 2,3,4 tubes at 3 cm in length) were embedded subcutaneously in model rats with endometriosis.The inhibition ratio on the endometriosis was measured 3 months later and compared with the placebo control group.RESULTS:In vitro mean drug release rate of about 9 ?g?d-1 was achieved for the one-tube implant at 3 cm in length for the first 15 days,but reduced to 5 ?g?d-1 after 30 days and which was maintained for over 6 months.Inhibition ratios of(18.6?17.3)%,(31.5?12.7)% and(72.2?12.3)% on the growth of endometrial explants were achieved after subcutaneous implantation of mifepristone-releasing implants(1 tube at 1.5 cm or 3 cm in length or 2 tubes at 3.0 cm in length),showing significance differences as compared with control group(P
