Compound Preparation of Yangshen and Chuanxiong for Cardiovascular Diseases
- VernacularTitle:洋参川芎复方制剂抗心血管疾病的实验研究
- Author:
Yu LIU
;
Lianxin LIU
- Publication Type:Journal Article
- Keywords:
Yangshen;
Chuanxiong;
Compound preparation;
Cardiovascular diseases;
Pharmacodynamics
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the efficacy of the compound preparation of Yangshen and Chuanxiong in the treatment of cardiovascular diseases. METHODS: The effect of the compound preparation of Yangshen and Chuanxiong on blood pressure of spontaneous hypertensive rats was observed. The myocardial ischemia model was established in rats by ligating coronary artery for the observation of the effect of the compound preparation on serum creatine phosphoric acid activating enzyme (CK), lactic dehydrogenase (LDH), malonaldehyde (MDA), and hyperoxide mutase (SOD). The ischemic cerebral edema model was established in rats by carotid ligation for the observation of the effect of the compound preparation on brain water content. The experimental thrombus model was established in rats by extracorporeal circulation for the observation of the effect of the compound on thrombus weight. The model of blood stasis was established in rats by injecting them with adrenalin hydrochloride for the investigation of the effect of the compound on whole blood viscosity. RESULTS: The compound preparation of Yangshen and Chuanxiong brought down the blood pressure in model rats significantly, increased serum levels of SOD and MDA as well as brain water content, inhibited the empirical thrombogenesis, and reduced the whole blood viscosities in rats with acute myocardial ischemia. CONCLUSION: The compound preparation of Yangshen and Chuanxiong has remarkable efficacy in anti-thrombosis, improving the cerebral circulation disturbance and cerebral oxygen supply, eliminating cerebral edema and promoting blood circulation to remove blood stasis.
