Optimization of Formula of Yanle Buccal Tablets by Pharmacodynamics Experiment
- VernacularTitle:药效学试验优选咽乐含片处方
- Author:
Ying CAI
;
Yumin WANG
- Publication Type:Journal Article
- Keywords:
Orthogonal test;
Yanle buccal tablets;
Optimization of formula
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the formula of Yanle buccal tablets. METHODS: 8 different formula were derived from L8(2)7 orthogonal design table taking 7 Chinese medicines as factors. The main outcome measures were granuloma growth inhibition test, ear swelling inhibition test and phenol red's phlegm eliminating test in mice. RESULTS: The results showed that that Radix et Rhizoma Slycyrrhizae and Flos Lonicerae Japonicae had significant impact on mice's granuloma growth inh-ibition test Result;Radix Ophiopogonis,Rhizome,Belamcandae,Semen Oroxyli,and Flos Lonicerae Japonicae had significant impact on mice's ear swelling inhibition test result; and Radix et Rhizoma Slycyrrhizae and Radix Platycodi had great impact on phenol red's phlegm eliminating test result in mice, suggesting that every Chinese medicine (factor) had effect on certain pharmacodynamic action. CONCLUSION: The original formula is the reasonable and optimum one.
