Study on dose-effect relationships in prevention and treatment of radiation-induced lung injury of rat with blood-cooling and blood flow-promoting drugs(凉血活血方)
- VernacularTitle:不同剂量凉血活血方防治大鼠放射性肺损伤的研究
- Author:
Minghui YANG
;
Yongqi DOU
;
Mingxiong LIN
;
Linchun FENG
;
Yi LIU
;
Yan YANG
- Publication Type:Journal Article
- Keywords:
prescription for cooling and promoting blood;
prevention and treatment of traditional Chinese medicine;
radioactive lung injury
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effects and dose-effect relationships of different doses of the blood-cooling and blood flow-promoting drugs(凉血活血方) on radiation-induced lung injury of rat.Methods Seventy-two Wistar rats were randomly allocated into four groups: irradiation group(group A),small-dose group(group B,9 g?kg-1?d-1),middle-dose group(group C,18 g?kg-1?d-1) and high-dose group(group D,36 g?kg-1?d-1).All groups were repeatedly exposed to small dose of X-ray in the right hemi-thorax,and then the mice were sacrificed at different time points.The living animal features,the macro-changes of lung were observed,and pulmonary histopathological changes in all the groups were investigated,and the results of observation were compared.Results The symptoms of red patches around the nose and dry stool in groups C and D were less than those of groups A and B.After 26 weeks,lung coefficient in groups B,C and D was the same as that in group A,but right lung wet weights and lung coefficients at each time point in groups B,C and D were significantly lower than those in group A,and during 5th week,the right lung wet weights in groups C and D were obviously lower than the weight in group B(all P
