Metoclopramide-induced Children Poisoning:Retrospective Analysis of 56 Cases
- VernacularTitle:甲氧氯普胺引起小儿中毒56例文献分析
- Author:
Jiansheng XING
;
Yongchun WANG
- Publication Type:Journal Article
- Keywords:
Metoclopramide;
Children;
Poisoning;
Retrospective analysis
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the incidence,the etiological factor and the harm of metoclopramide-induced children poisoning.METHODS:We reviewed 30 reports published in Chinese Pharmaceutical Abstracts(2003～2006)and domestic pediatric journals and gave a comprehensive evaluation on the confirmed 56 metoclopramide-induced children poisoning cases.RESULTS:All of the 56 poisoning cases were induced by oral administration and all had high daily dose.The condition was predominantly characterized by posterior tilt of head,stiffing of root of tongue,ataxia,upward staring or side-glance etc.Metoclopramide has inhibition effect on leucocytes,and it can result in cumulative poisoning,especially for children with hepatorenal inadequacy.CONCLUSION:Great attention should be attached to the dose and course of treatment of metoclopramide to enhance drug efficacy while reducing incidence of adverse drug reactions.
