Calculation of Pharmacokinetic Parameters and Two-Compartment Model's Parameters by Extravascular Administration Based on Excel Function
- VernacularTitle:基于Excel函数求解血管外给药二室模型的药动学及隔室模型参数
- Author:
Jin YUAN
;
Lei SHI
;
Shujin ZHAO
- Publication Type:Journal Article
- Keywords:
Excel;
Residual method;
Two compartment model by extravascular administration;
Pharmacokinetics;
Compartment model;
Parameter
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To calculate pharmacokinetic parameters and compartment model's parameters by extravascular administration based on Excel function.METHODS:The parameters of pharmacokinetics and compartment model were calculated using residual method and Excel function.RESULTS:Excel can be used to directly demonstrate calculation process of parameters of pharmacokinetics and compartment model,with calculation results in line with those stated in textbooks.CONC-LUSION:The established method is simple,direct-viewing,reliable and easy to be extended,and it can be used to calculate pharmacokinetic parameters in clinical teaching or experiments.
