Hepatic arterial injection of recombinant adenovirus microspheres carrying antisense multidrug resistance-associated protein gene for hepatocellular cancer in rats
- VernacularTitle:包载反义MRP重组腺病毒微球肝动脉注射治疗肝癌的实验研究
- Author:
Xiaobo WANG
;
Shaohong YU
;
Lunan YAN
;
Yongbing CHEN
- Publication Type:Journal Article
- Keywords:
Carcinoma,Hepatocellular/ther;
MRP,Antisense;
Adenoviruses,Recombinant;
Microsphere;
Hepatic Arterial Injection
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate recombinant adenovirus microspheres encapsulated with antisense MRP(as-mrp) on reversion of hepatocellular carcinoma.Methods The rats were divided randomly into 5 groups:control group;hepatic arterial injection of normal saline group,microspheres carrying no viruses group,rAdV carrying as-mrp group,and microspheres with encapsulation of as-mrp rAdV(MER) group.The theraputic effect were observed.Results The tumor growth inhibition and the mean life time in MER group were superior to than of other 4 groups(P
